I've taken to using HootSuite as a primary Twitter client primarily as an interface to view various lists. I'm following the Baja 1000 off road race this week and while I'm looking for updates on the race I don't care so much about the web developers and other topics I follow. Next week I'll be back to looking for insight on various development topics and the late tweets on how hard the racers and their crews partied in Ensenada or La Paz don't matter much to me.

HootSuite doesn't have the prettiest interface but it is functional and reasonably fast for a web client so it works for me.